|
rs972936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification by apolipoprotein E (APOE) ɛ4-carrying status, rs972936</span> polymorphism was only significantly associated with LOAD in non-ApoE ɛ4 allele carriers (genotype P = 0.002, allele P = 0.039).
|
23089282 |
2012 |
|
rs950809
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, haplotype analyses revealed that, in the LOAD group, the frequency of haplotypes C-C-G-T-C (alleles in order of rs17277986, rs6584777, rs10884402, rs7078098, rs950809 polymorphisms) were significantly higher (Psim<0.0001) while haplotype C-C-A-T-C, C-C-A-C-C, T-T-A-C-C were significantly lower (Psim<0.0001).
|
23700427 |
2013 |
|
rs9472817
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We recently reported that rs9472817-C/G, an intronic variant of neuronal mitochondrial uncoupling protein-4 (<i>UCP4/SLC25A27</i>) gene affects the risk of late onset Alzheimer's disease (LOAD), and that the variant's effect is strongly dependent on <i>APOE</i>-ε4 status.
|
30425186 |
2018 |
|
rs9340803
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, we performed the targeted-sequencing of 12 nuclear receptor genes plus <i>APOE</i> which were involved in cholesterol content modulation to screen susceptible genetic variants and focused on a new risk variant <i>ESR1</i> rs9340803 at 6q25.1 for both late-onset Alzheimer's disease (OR=3.30[1.84~4.22], <i>p</i><0.001) and mild cognitive impairment (OR=3.08[1.75~3.89], <i>p</i><0.001).
|
30222591 |
2018 |
|
rs9331949
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Logistic analysis identified the rs9331949 polymorphism was still strongly associated with LOAD (additive model: p = 0.004, odds ratio = 1.274; dominant model: p = 0.039, odds ratio = 1.239; recessive model: p = 0.002, OR = 1.975) after adjusting for sex, age, and APOE ε4 status.
|
23411014 |
2013 |
|
rs9331949
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, we have identified that the locus (rs9331949) located in the binding site of 3' UTR of CLU has a strong association with LOAD rather than loci in LPL and LRP6.
|
27897113 |
2017 |
|
rs906454643
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Novel presenilin 1 mutation (Ile408Thr) in an Italian family with late-onset Alzheimer's disease.
|
26549787 |
2016 |
|
rs890293
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Participants with GT or TT of rs890293 and CG or GG of rs1805192 genotype have the highest LOAD risk.
|
27396818 |
2017 |
|
rs821616
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As for rs821616 and rs3738401, no association was detected with LOAD.
|
27023224 |
2017 |
|
rs802571
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data indicated that 18p11.32 (rs1992269, P = 9.77 × 10(-7)), CNTNAP2 (rs802571, P = 1.26 × 10(-6)), and 12q24.23 (rs11613092, P = 6.85 × 10(-6)) were suggestive loci for susceptibility to LOAD.
|
26049409 |
2015 |
|
rs80001089
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There is also significant epistatic relationship (p = 0.0410) between UNG rs80001089 and NEIL1 rs7182283 in TC from LOAD subjects.
|
31415677 |
2019 |
|
rs7910977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the minor allele of rs7910977 associated significantly (p = 0.0046) with reduced LOAD risk (OR = 0.81 with a 95% CI of 0.70-0.94), as expected biologically from its association with elevated IDE expression.
|
20142614 |
2010 |
|
rs7908652
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of these SNPs, 5 SNPs (rs4669573 and rs10197851 on 2p25.1; rs11711889 on 3q25.2; rs1117750 on 7p21.1; and rs7908652 on 10q23.1) were associated with LOAD in an independent cohort from the National Institute on Aging Late-Onset Alzheimer's Disease Family Study.
|
21059989 |
2011 |
|
rs7856774
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate analysis showed association between rs7856774 and LOAD, independently from the effect of APOE variation.
|
22785395 |
2012 |
|
rs7764257
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A recent large study has identified significant association of two single nucleotide polymorphisms (SNPs) (rs2651206 and rs7764257) in the TTBK1 gene with late-onset Alzheimer's disease (LOAD) in Spanish.
|
21219968 |
2011 |
|
rs775494528
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Follow-up genotyping analysis revealed that a novel missense mutation P318L appeared to exert risk effect for development of LOAD; and rs67327804 was also significantly associated with LOAD risk even after adjusting for age, gender, and apolipoprotein E ε4 status.
|
24582639 |
2014 |
|
rs772635342
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association has been replicated in a Han Chinese cohort, two rare variants p.I163M in exon7 and p.R356H in exon11 of <i>PLD3</i> were found to be associated with LOAD risk.
|
30837833 |
2019 |
|
rs772069024
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The link between Val232Met variant of phospholipase D3 (PLD3) and late-onset Alzheimer's disease (AD) is still obscure.
|
31121321 |
2019 |
|
rs771608420
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A variant in <i>AKAP9,</i> p.R434W, segregated significantly with LOAD in two large families (OR = 5.77, 95% CI: 1.07-30.9, <i>P</i> = 0.041).
|
29688227 |
2018 |
|
rs770510230
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A stop-gain mutation in ABCA7 (E1679X) and missense mutation in CD2AP (K633R) were highly significant in Caucasian LOAD cases, and mutations in EPHA1 (P460L) and BIN1 (K358R) were significant in Caribbean Hispanic families with LOAD.
|
26101835 |
2015 |
|
rs770461695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A stop-gain mutation in ABCA7 (E1679X) and missense mutation in CD2AP (K633R) were highly significant in Caucasian LOAD cases, and mutations in EPHA1 (P460L) and BIN1 (K358R) were significant in Caribbean Hispanic families with LOAD.
|
26101835 |
2015 |
|
rs76863441
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There were no associations between AvrII iPLA2 and Val279Phe PAFAH polymorphisms and LOAD.
|
20464283 |
2010 |
|
rs768623239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the association of GSTM1 and GSTT1 null deletion and GSTP1 313 A/G polymorphisms and the risk of AD in an Iranian population.
|
29072550 |
2018 |
|
rs766662990
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined whether DNA-polymorphisms at the genes encoding chemokines MCP-1 (-2518 A/G) and RANTES (-403 A/G), and chemokine receptors 5 (CCR5, Delta32) and 2 (CCR2,V64I), were associated with the risk and/or the clinical outcome of LOAD and PD.
|
15488313 |
2004 |
|
rs765670175
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The best studied N141I mutation produces an Alzheimer's disease phenotype with a wide range of onset ages overlapping both early and late onset Alzheimer's disease, often associated with seizures, high penetrance and typical Alzheimer's disease neuropathology.
|
20375137 |
2010 |